PENGARUH EKSTRAK ETANOL DAUN KARANDA (Carissa carandas L.) TERHADAP HISTOPATOLOGI GINJAL TIKUS PUTIH (rattus norvegicus) YANG DIINDUKSI ALOKSAN
نویسندگان
چکیده
Suatu kondisi metabolik yang disebut diabetes melitus (DM) diakibatkan oleh ketidakmampuan untuk mengeluarkan insulin. Tujuan penelitian ini adalah mengetahui pengaruh pemberian ekstrak etanol daun karanda (Carissa carandas L.) terhadap morfologi dan histologi ginjal tikus diabetes. Penelitian menggunakan Rancangan Acak Lengkap (RAL) dengan enam kelompok variasi yaitu glibenklamid, kontrol normal, negatif. P1: dosis 500 mg/kg BB, P2: 750 P3: Dosis 1000 BB. Pewarnaan hematoksilin-eosin (HE) metode parafin preparasi histopatologi tikus. Tes tindak lanjut Anova Duncan digunakan dalam analisis data satu metode. Temuan menunjukkan perbedaan substansial antara perlakuan Histologi edema glomerulus, destruksi sel berupa degenerasi hidropik nekrosis tubulus proksimal, serta modifikasi lebar glomerulus. Pemberian dapat membantu mengatasi bentuk, penyembuhan proksimal. Mungkin relevan bahwa ginjal, histologi, diameter glomerulus (Rattus norvegicus) mellitus ditingkatkan karanda, paling efektif mg/kgbb.
 Kata Kunci : Diabetes Melitus, Daun Karanda Ginjal
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ژورنال
عنوان ژورنال: Jurnal Farmasi Udayana
سال: 2023
ISSN: ['2301-7716', '2622-4607']
DOI: https://doi.org/10.24843/jfu.2023.v12.i01.p05